Pair Name | 20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand | ||
Phytochemical Name | 20(s)-ginsenoside Rh2 (PubChem CID: 119307 ) | ||
Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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2D
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MOL
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Pair Name | 20(s)-ginsenoside Rh2, TNF-related apoptosis inducing ligand | |||
Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
Down-regulation | Expression | CASP3 | hsa836 | |
Down-regulation | Cleavage | CASP8 | hsa841 | |
Down-regulation | Cleavage | PARP1 | hsa142 | |
Up-regulation | Expression | TNFRSF10B | hsa8795 | |
Down-regulation | Expression | XIAP | hsa331 | |
In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
OV2944-LM-3 | Malignant ovarian neoplasm | Mus musculus (Mouse) | CVCL_E956 | |
L-02 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_6926 | |
In Vivo Model | Human hepatocellular carcinoma cells HepG2 (5×10⁵) in the log phase were implanted subcutaneously (s.c.) in the flanks of mice. | |||
Result | Our study indicates that Rh2 may act as a sensitizer in combination with TRAIL to increase the efficacy of its anti-tumor activity. |
No. | Title | Href |
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1 | 20(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cells. Med Oncol. 2022 May 15;39(5):70. doi: 10.1007/s12032-022-01663-6. | Click |